At least four people have been killed after a large car bomb explosion struck Cairo's police headquarters.
The bombing came on the eve of the anniversary of the start of the 2011 uprising that toppled Egypt's ruler Hosni Mubarak.
Sky's Middle East news editor Tom Rayner said: "Egyptian state television is quoting an official saying this was a car bomb."
The explosion sent a large plume of smoke billowing above the city and left a deep crater in the street.
It is unclear how the car bomb was brought so close to the police headquarters, which is surrounded by a high metal fence.
The explosion happened in the Egyptian capital The dead include three policemen, according to reports, and more than 40 people are said to be injured.
State television quoted witnesses as saying gunmen on motorcycles opened fire on buildings after the explosion.
Onlookers at the scene of the blast shouted "traitors and dogs" in apparent reference to the assailants.
People also chanted anti-Brotherhood slogans. "The people want the execution of the Brotherhood. Execution for Mursi."
Militants have escalated attacks since the military overthrow Islamist president Mohamed Morsi in July.
Morsi's Muslim Brotherhood has denied involvement in the attacks, but was blacklisted as a terrorist group after 15 people were killed when a suicide bomber blew up a vehicle at a police headquarters north of Cairo in December.
More follows...
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